2 In women presenting with elevations in blood pressure in the latter half of pregnancy (defined as a sustained elevation in blood pressure of ≥ 140 mm Hg systolic and/or ≥ 90 mm Hg diastolic), detailed laboratory evaluations are essential to determine whether a patient has a diagnosis of preeclampsia, including assessment of proteinuria, platelet count, and liver and renal function testing. 1, 2 The latest analysis by the World Health Organization suggests that, in developed countries, 16% of maternal deaths in pregnancy were a result of hypertensive disorders. Hypertensive disorders complicate 5% to 10% of all pregnancies and are associated with significant maternal morbidity and mortality.

Conclusions: Compared with 24-hour urinary protein excretion, the spot urinary ACR may be a simple, convenient, and accurate indicator of significant proteinuria in women with preeclampsia. The optimal spot ACR cutoff point was 22.8 mg/mmol for 0.3 g/24 h of protein excretion (mild preeclampsia) with a sensitivity and specificity of 82.4% and 99.4%, respectively, and 155.6 mg/mmol for 2 g/24 h of protein excretion (severe preeclampsia) with a sensitivity and specificity of 90.6% and 99.6%, respectively. Results: A strong correlation was evident between the spot ACR and 24-hour urinary protein excretion ( r =. Receiver operating characteristic curve analysis was used to determine the best cutoff values of the spot ACR for mild preeclampsia (proteinuria ≥ 0.3 g/24 h) and severe preeclampsia (defined in China as proteinuria ≥ 2 g/24 h). The correlation between the spot ACR and 24-hour urine protein excretion was assessed, and the diagnostic value of ACR was expressed in terms of specificity and sensitivity.

ACR was determined in a spot midstream urine sample and the amount of protein excretion was quantified in a 24-hour urine collection performed the following day. Methods: ACR and 24-hour urinary protein excretion were measured in 50 consecutive patients with preeclampsia. Aim: To assess whether a single urinary spot urinary albumin:creatinine ratio (ACR) can be used to estimate 24-hour urinary protein excretion in women with preeclampsia.

0.3 mg to g